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Phentermine and Topiramate Weight Loss

In July of 2012, the United States Food and Drug Administration (FDA) approved a new weight loss drug called Qsymia. This is a combination medication with two existing medications that are generic – Phentermine(Adipex or Bontril) and Topiramate (Topamax).

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If you are overweight or obese, and need help losing weight, W8MD can help. Accepting most insurances, with an evidence based practice, with many locations in the US with physicians and staff experienced and well trained, W8MD has helped thousands of patients lose weight and is ready to help you. W8MD’s insurance physician weight loss program offers FDA appetite suppressants or diet pills such as PHENTERMINE (ADIPEX), QSYMIA, BELVIQ, SAXENDA, TENUATE(DIETHYLPROPION), BONTRIL (PHENDIMETRAZINE) etc. We also offer optional and delicious VLCD meal replacements for fast weight loss results. In addition to weight loss, W8MD offers state of the art Sleep Medicine,  IV Therapy, and Medical Aesthetics / Spa services. Book Appointments or call (800)W8MD-007. Read success stories...

Phentermine and Topiramate Weight Loss

Generic Combination of Phentermine and Topiramate* is an option available after consultation with W8MD Physicians

As the manufacturer brand name cost of the medication at $250-275 per month is a bit high for many people trying to lose weight, some of our patients requested us on the generic combination with the same dose.

Realizing the significant cost benefit to our patients, W8MD Medical Weight Loss Centers program in New York City, King Of Prussia and New York City have prescribed the generic combination of Phentermine, and Topiramate for significant cost saving and with very good results.

As each of these components for weight loss pill can be as cheap as $50 USD for a month supply, you will only pay about $60.00 per month for both Phentermine and Topiramate in the generic combination as opposed to about $160 for a month supply of Qsymia.

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Here is the information from the FDA on the new weight loss medication Qsymia

The U.S. Food and Drug Administration today approved Qsymia (phentermine and topiramate extended-release) as an addition to a reduced-calorie diet and exercise for chronic weight management.

The drug is approved for use in adults with a body mass index (BMI) of 30 or greater (obese) or adults with a BMI of 27 or greater (overweight) who have at least one weight-related condition such as high blood pressure (hypertension), type 2 diabetes, or high cholesterol (dyslipidemia).

BMI, which measures body fat based on an individual’s weight and height, is used to define the obesity and overweight categories. According to the Centers for Disease Control and Prevention, more than one-third of adults in the United States are obese.

“Obesity threatens the overall well being of patients and is a major public health concern,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research. “Qsymia, used responsibly in combination with a healthy lifestyle that includes a reduced-calorie diet and exercise, provides another treatment option for chronic weight management in Americans who are obese or are overweight and have at least one weight-related comorbid condition.”

Qsymia is a combination of two FDA-approved drugs, phentermine and topiramate, in an extended-release formulation. Phentermine is indicated for short-term weight loss in overweight or obese adults who are exercising and eating a reduced calorie diet. Topiramate is indicated to treat certain types of seizures in people who have epilepsy and to prevent migraine headaches.

Qsymia must not be used during pregnancy because it can cause harm to a fetus. Data show that a fetus exposed to topiramate, a component of Qsymia, in the first trimester of pregnancy has an increased risk of oral clefts (cleft lip with or without cleft palate). Females of reproductive potential must not be pregnant when starting Qsymia therapy or become pregnant while taking Qsymia.

Females of reproductive potential should have a negative pregnancy test before starting Qsymia and every month while using the drug and should use effective contraception consistently while taking Qsymia.

The safety and efficacy of Qsymia were evaluated in two randomized, placebo-controlled trials that included approximately 3,700 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced calorie diet and regular physical activity.

The recommended daily dose of Qsymia contains 7.5 milligrams of phentermine and 46 mg of topiramate extended-release. Qsymia is also available at a higher dose (15 mg phentermine and 92 mg of topiramate extended-release) for select patients.

Results from the two trials show that after one year of treatment with the recommended and highest daily dose of Qsymia, patients had an average weight loss of 6.7 percent and 8.9 percent, respectively, over treatment with placebo. Approximately 62 percent and 69 percent of patients lost at least five percent of their body weight with the recommended dose and highest dose of Qsymia, respectively, compared with about 20 percent of patients treated with placebo.

Patients who did not lose at least three percent of their body weight by week 12 of treatment with Qsymia were unlikely to achieve and sustain weight loss with continued treatment at this dose. Therefore, response to therapy with the recommended daily dose of Qsymia should be evaluated by 12 weeks to determine, based on the amount of weight loss, whether to discontinue Qsymia or increase to the higher dose. If after 12 weeks on the higher dose of Qsymia, a patient does not lose at least five percent of body weight, then Qsymia should be discontinued, as these patients are unlikely to achieve clinically meaningful weight loss with continued treatment.

Qsymia must not be used in patients with glaucoma or hyperthyroidism. Qsymia can increase heart rate; this drug’s effect on heart rate in patients at high risk for heart attack or stroke is not known. Therefore, the use of Qsymia in patients with recent (within the last six months) or unstable heart disease or stroke is not recommended. Regular monitoring of heart rate is recommended for all patients taking Qsymia, especially when starting Qsymia or increasing the dose.

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The FDA approved Qsymia with a Risk Evaluation and Mitigation Strategy (REMS), which consists of a Medication Guide advising patients about important safety information and elements to assure safe use that include prescriber training and pharmacy certification. The purpose of the REMS is to educate prescribers and their patients about the increased risk of birth defects associated with first trimester exposure to Qsymia, the need for pregnancy prevention, and the need to discontinue therapy if pregnancy occurs. Qsymia will only be dispensed through specially certified pharmacies.

Vivus Inc. will be required to conduct 10 postmarketing requirements, including a long-term cardiovascular outcomes trial to assess the effect of Qsymia on the risk for major adverse cardiac events such as heart attack and stroke.

The most common side effects of Qsymia are tingling of hands and feet (paresthesia), dizziness, altered taste sensation, insomnia, constipation, and dry mouth. Qsymia is marketed by Vivus Inc. in Mountain View, Calif.

Call W8MD to learn more about the generic or brand name Qsymia available after a consultation with our weight loss doctor.

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W8MD’s insurance weight loss program is unique in many ways with a comprehensive multidisciplinary approach to losing weight fast that addresses all the complex issues leading to weight gain, both in adults and children. Since its inception in 2011, W8MD has successfully helped thousands of patients lose weight successfully succeed in not only losing weight but also keep it off with an ongoing maintenance plan.

We offer FDA appetite suppressants or diet pills, such as Phentermine or Adipex, Qsymia, Belviq, Saxenda, Contrave, Bontril, Tenuate etc. We also offer very low calorie diets (VLCD),with optional and affordable insulin resistance

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